Now see that's the interesting thing about these runes, they don't say (non stackable) like an attribute rune does so that is very confusing.
Vitae I can see stacking
Attunement (or whatever the +2 energy is called) I can see stacking
These new ones not so sure, getting 100% reduction would make any of the 2 combos on you totally useless, which is kind of cool and you do sacrifice having any other runes in but may not really be balanced.
I think its very balanced as stacking. If you want to sacrifice other runes to use these then go right ahead. Dazed and Deep wound are pretty powerful conditions.