My mouse has been acting up during GW

In the last few days my mouse won't work,usually right in the middle of a battle.But when I leave GW it works fine.Its a wirless mouse on a dell pc.Its driving me crazy,I can't do anything without constantly reseting the mouse with a little button under it.Which only helps for a couple of seconds.I replaced the batteries last night but no help! Is this a software issue from the game?