+15 while attacking is always nice to use.
but still there are other armors that can be used for better use..
like +10 vs physical then +10 vs piercing is great if u are ganking etc.
but i'd say +15 while attacking is a good general armor.
It all depends on build. I have several sets of armor on all my characters with different runes/insignias for all the builds I use. Do what works best for your build.