Can i disable alt f4?

Can I disable its command while playing, or change it to something competely different (that wont kill my game).

Don't press it.

Alt+F4 is a Windows command not a Guild Wars command.

If you want, you can go into the keybinding menu in Guild Wars and change it so Alt+F4 is another command entirely if you don't want to it kill your game. I'm going to check this first. Though I imagine it might work since it would override it in the game...

Have you been falling for:

"Press Alt-F4 for free gold/items/faction/win"?

Yes that, and also my Alt key is Push to Talk, and my F4 key will drop the flag to my weapon set 4, so if Im calling a drop spike then ill leave.

easy, just change your push to talk key to something else or change the weapon slot 4 for something else than F4. Easier than changing the windows key bindings.