Single Paragon, Normal Mode:
Aggressive Refrain
Go For The Eyes!
Defensive Anthem/Expel Hexes/Cruel Spear
There's Nothing To Fear!
Anthem of Flame
Wild Throw
Spear of Lightning
Signet of Return
Spear Mastery: 11 + 1
Leadership: 10 + 1 + 1
Command: 10 + 1
Fairly basic, I'll go over the elite choices and when you would want to use them.
Defensive Anthem
Generally you'll want to use Defensive Anthem in situations where your party is more caster oriented. If your team is more heavy on physicals, a lot of the effectiveness of this skill is lost. If you are newer to the paragon profession or just looking for something that will work in just about any area, the 50% block will be much appreciated from the softer targets.
Expel Hexes
Expel I reserve for the Fissure of Woe, Realm of Torment, and the Desolation mostly. Each area carries a number of troublesome hexes for physicals (Faintheartedness, Spiteful, etc.) that can wreck groups if they sit for their full duration. Vocal Minority especially; I hate losing my Aggressive Refrain.

Cruel Spear
Basically in the opposite group as the Defensive Anthem. In a party more physical heavy it never hurts to have multiple deep wounds.
Defensive Anthem Chain, Normal or Hard Mode:
Paragon Two :
Aggressive Refrain
Merciless Spear
Spear of Lightning
Defensive Anthem
Signet of Return
Go For The Eyes/Never Surrender (Areas where you're expecting longer encounters the extra emangement is helpful)
Anthem of Weariness
Anthem of Envy/They're On Fire! (In the presence of a fire ele + not as many physicals)
Spear Mastery: 10 + 2
Leadership: 12 + 1 + 1
Command: 8 + 1
In areas where I run two paragons it's generally because the added passive defense takes a lot of the workload off the monks. Be aware that paragon heroes are completely oblivious to Defensive Anthem; they'll use it even if they're currently affected by it. As a result you have to wait for your hero to use it before you do. Otherwise they'll overlap and much of the uptime is lost, and if you're loading two DA paragons I'm going to assume it's because you need the passive defense to succeed.
This setup I used personally for most of my Legendary Guardian, and whenever I get to bring my paragon hero with me to Urgoz.
I don't need to try mode, three paragons:
Paragon Three:
Aggressive Refrain
Go For The Eyes!
The Power Is Yours!/Song of Purification
Aria of Zeal
Lyric of Zeal
Wild Throw
Spear of Lightning
Signet of Return
Leadership, Spear Mastery, Motivation: 12
Command: Leftovers
My new setup since I got Hayda when I don't feel like doing any work. Casters never run out of energy, your softer targets are protected with the DA chain, the only way you're going to get beat is through a lot of armor ignoring damage. Generally we'll have the monks use Signet of Rejuvenation or Devotion to benefit from the +7 energy return from Lyric of Zeal. My typical setup is this + an SS hero or an Earth Shaker warrior.
Note this build is also effective if you're the only paragon and you want to play the Motivation role, however be aware that if you decide to carry There's Nothing To Fear! you will need to manage your energy with The Power Is Yours!.
Urgoz, The Deep, and DoA:
Aggressive Refrain
Save Yourselves! (At least 4 seconds)
Focussed Anger
There's Nothing To Fear!
For Great Justice!
Vicious Attack
Spear of Lightning
Signet of Return
Spear Mastery: 10 + 1 + 1
Leadership: 11 + 1
Command: 10 + 1
For Save Yourselves! to truly be effective, it has to be your only adrenaline skill, especially if you don't have a high enough rank in the faction titles. The number one priority of this build is to maintain the +100 AL with as little downtime as possible, which means all of your adrenaline will go towards this skill and you're going to maintain a constant double adrenaline gain rate. Simply put, if you're putting Save Yourselves! on your bar it's because you're expecting to receive a lot of hard hits. But that doesn't mean you can't also support the party with damage of your own, SY! will provide a lot of energy so you might as well put it to use.
If you choose to, you could use Spear of Fury. I personally don't like the aftercast delay and the additional adrenaline gain is not necessary for SY!.
In the times I've done Urgoz with this build, I've only run it when I cannot take my DA partner and we have a human warrior capable of managing Save Yourselves! (read, Dragon Slash warrior).
When it comes to DoA, I will play this paragon regardless. The amount of damage you will prevent allows for much wider margin of error, and in an elite mission that is always a plus. Should I carry a paragon hero, I will bring the motivation setup. Titan encounters and multiple group aggros can be stressful on your casters if you're enraging too many enemies.
Why run two, even three paragons?
Passive defense is a powerful tool, and if you're playing a primary paragon you are probably already aware of the benefits of using it. You can make mistakes, in some instances enough to handle multiple mobs of enemies with little effort. Party wide defenses, energy support, the armor level of a warrior and comparable damage to one too.