Making friends is easy.... making good friends who talk to you and have time for each other is harder. In our guild we have a real core set of players who are also good friends, and people who met through the guild.
I have been in the guild for nearly 2 years and guild leader for 18 months of that. I know some real good people through it and have met a fair few of them IRL also. We also use Teamspeak which also breaks down some of the barriers.
However it is harder to get friends outside of your guild/alliance as it were... some come and go, some talk with you but not always.
Plus I guess I should admit... I met the person I am going to marry via this game... knew each other for quite a while, started going out and now engaged to be married.... and yes we have met in person for the skeptics.. we do as much as we can, which is every weekend near as we can
Friendships can be got, even more can be got if your lucky