Wow it's so nice how the guru community is again with Epic QQ'rs. "Zomg Fail +1 postcount"
Guru is supposed to help newbz, not QQ over them. Ok he formulated the question wrong, and put it in the wrong forum section. But it doesn't make the question non valid.
If one would have only the Nightfall campaign, what build + hero's would be the most efficient at steam rolling through the PVE scape?
First Up state your profession. Which games you own, and what hero's. Also just have a look in the builds section of this forum. You could go to
http://www.pvxwiki.com/wiki/Main_Page to check out some builds, and change the meta for your own.
I still stand with MM jagged bones + death nova for meat shield, and a lot of damage. Searing Flames ele for burning condition + damage. And a paragon with They're on Fire! + Watch yourself & perhaps some motivation shouts for party heal. Could also go Go for the Eyes for crit damage on the minions.