Popular choices I've seen with Moebius Strike and Death Blossom that makes stuff explode in high level PvE areas generally has Golden Fang Strike in the build. The base template is normally something like this, and is pretty much the optimal build for serious damage that supplies AoE also with an Assassin in PvE:
[build prof=A/any name="Death Blossom" dag=12+1+1 cri=12+1][Critical Agility][Critical Eye][Unsuspecting Strike][Golden Fang Strike][Death Blossom][Moebius Strike][Optional][Resurrection Signet][/build]
Popular optionals are (but not restricted to):
"Save Yourselves!" (Reccomended)
Death's Charge
"I Am The Strongest!"
Assassins Remedy
"You Move Like a Dwarf!" (For snaring and interrupts).
Critical Defenses (Reccomended)
Brawling Headbutt (For spamming knockdowns)
Restful Breeze
Different lead, offhands, and dual attacks such as:
Golden Fox Strike and Wild Strike can be used to provide stance removal against stance blocking
Sneak Attack
Golden Phoenix Strike could also be used to open up a second optional slot, at the cost of losing Deep Wound from Golden Fang Strike (Reccomended to have cover enchantments to ensure you can land it).
Critical Strike is a common replacement for Critical Eye as alot of people like the energy on demand, I however find it unnessacary with Critical Eye as you keep the critical hit rate up giving higher DPS overall and it takes seconds to regain energy by auto attacking should you need to.
Twisting Fangs (Taken alongside Golden Fox Strike and Wild Strike normally as a source of Deep Wound)
Here's are some examples of builds using different leads and offhands alongside Moebius Strike and Death Blossom:
[build prof=A/any name="Death Blossom" dag=12+1+1 cri=12+1][Critical Agility][Critical Eye][Golden Fox Strike][Wild Strike][Death Blossom][Moebius Strike][Twisting Fangs][Resurrection Signet][/build]
[build prof=A/any name="Death Blossom" dag=12+1+1 cri=12+1][Critical Agility][Critical Defenses][Critical Eye][Golden Phoenix Strike][Death Blossom][Moebius Strike][Twisting Fangs][Resurrection Signet][/build]
The Moebius Strike and Death Blossom combo is also a popular choice in Assassin farming methods. Here is the solo farming variant commonly run today since the Mystic Regeneration nerf that is capable of farming areas on Hard Mode:
[build prof=A/Mo name="Death Blossom" dag=11+1 cri=10+1+2 healin=10][Golden Phoenix Strike][Critical Strike][Moebius Strike][Death Blossom][Critical Defenses][Critical Agility][Vigorous Spirit][Live Vicariously][/build]
Conclusion
I've only touched the tip of the iceberg, seriously. Moebius Strike and Death Blossom is a strong and versatile combo with much room for running different variants that can be quite effective in the majority of areas. There isn't an Assassin build in PvE that matches it for sheer DPS and AoE together with such a short recharge on the skills (that are normally recharged by Moebius Strike anyway). It IS unsuitable in some areas, but those areas ARE few and far between and that DOES make taking Moebius Strike and Death Blossom the "Definitive Assassin build for PvE"
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