[build name=A-E Ultimate Runner NM prof=A/E shadow=12+2+1 deadly=12][Deadly Paradox][Glyph of Swiftness][Shadow Form]["I Am Unstoppable!"][Dark Escape][Death's Charge][Feigned Neutrality][Shadow Sanctuary][/build]
[Drunken Master] is also an option instead of Dark Escape or Feigned Neutrality, if you're the drinking type. I personally like my screen undistorted when I run lol.
You can also drop one of the last 2 skills (depending on which is better for you) and take Dash for an little extra running. I find that I rarely need the regen, so I like an extra running skill.
Equipment: any staff with +10 energy and +20% enchanting wrapping, energy+5 head and an energy+5 '^50%hp' or 'when enchanted' inscription.
Major shadow arts on the headpiece. (or superior, but major works)
attunement runes 4x.
radiant insignias 5x.
for traps, bleeding or poison: Feigned Neutrality or Shadow Sanctuary.
for blockage between enemies: Death's Charge. (or Viper's Defense)
Try to find out where traps can be expected, so you can use "I Am Unstoppable!" before you risk being crippled. Same goes for shadow and wurm-popups. Shadows can be especially annoying as they will ALL cast signet of Judgement on you, and not only Knock you down, but deal damage as well. You really want to be far away from them as fast as possible, so hit IAU! as soon as one pops up and use a running skill.
This build might also be excellent for exploration! You can simply run anywhere without worries, without having to kill every damn enemy you encounter (except in missions). Excellent!

I have yet to try this, I'll do a Droknar run with it as soon as I have the time.
Any feedback or corrections are welcome! ~Sjeng
06-03-2008 edit:
I tweaked it a bit after some testing, did two Droknar runs (with one mess-up because of Shadows with Signet ambush, but thanks to the Grenth's Footprint gate, I was able to finish it anyway) and I find this to be even more efficient:
[build name=A-E Ultimate Runner NM prof=A/E shadow=12+2+1 deadly=12][Deadly Paradox][Glyph of Swiftness][Shadow Form]["I Am Unstoppable!"][Drunken Master][Dark Escape][Death's Charge][Shadow Sanctuary][/build]
Even without drinking and low Norn rank, this works great. The higher your norn rank, the easier it gets.