Personally I use a nasty Splinter/Regen build, with a ritualist as secondary class.
Quite simply, the synergies are par none. First of all you have the scythe, which hits in a narrow spread. I have a few points in channeling for splinter which hits adjacent enemies to whatever is hit. So right there, say i have a mob, the scythe hits the three in front of me, and the splinter hits another three around them. Next, i have an enchantment to increase attack speed, and add burnign when it ends, and enchantment that give me +xxx health per enchantment for each hit. I have zealous renewal, which does damage on casting and then +energy for each hit while it was active. Avatar of balthazar for +40 armor and increased speed. Armor-wise my pieces all have windwaker sigs, which add +5 armor for each enchantment to a max of 25 i believe. And then i have a few scythe skills to round it out, to deal extra damage to the primary target, one which gives health on hit, and the other which adds energy.
So overall, i'm a monster in mobs, with a total of +65 armor at any given time, I hit about 6-10 enemies and get 45 health from each one. I hit with increased speed, and get health and energy constantly. Oh yeah and i forgot eternal aura, so balthazar is PERMANENT.
