most missions can be run in some form or another. however, if you go to a place and theres no runner, its probably because:
a) not enough traffic for it to be profitable
b) no good place for payment so people get stiffed a lot
c) it takes too long, or is too much of a pain to repeat often.
a lot of missions are fairly easy, but the time involved isnt equal to the price people are willing to pay. this is basically because with experience comes gold, but once they have the experience they dont need you to run em. so they either have both experience and gold, or neither. both of which are not going to buy a run from you
so basically only a few are even worth the effort