I usually put plenty of interrupt skills on my heroes. I bring one hero packed full of interrupts (and Discord or lots of Domination to deal damage). Sometimes I scatter inspiration interrupts (and maybe power return) among the heroes for interrupt and energy management. Dragging along the one 'interrupt' henchman is usually not enough to avoid getting splattered by multiple AoE's.
I've been trying various popular hero build teams, like discordway, sabway, racway, etc...and getting destroyed in some areas. A few mobs casting AoE's on my team is enough to wreck them. If I had my usual interrupt hero along, she'd shut them down and it would have been a cakewalk.
How are you guys playing without interrupts...especially in hard mode?
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