Populated, I would probably say Nightfall if only due to the trading hub there and the fact people go through it for unlocking heroes. But they're all spread out, and aside from the trading hub named Kamadan (affectionately nicknamed Spamadan), people only really group up to do elite areas or the latest daily mission or bounty, which can be obtained from Embark Beach. So it isn't that big a concern.
To start in a campaign, I'd probably select Factions for the fastest leveling and the shortest campaign. From there you can either rush through the campaign, or go to Nightfall for heroes, Eye of the North for PvE skills + heroes, or Prophecies to get the first campaign out of the way. Nightfall would be the second best choice for a decent pacing, but there is some forced grind in that you need to raise the Sunspear and Lightbringer reputation titles to progress at certain points.
Quote:
Originally Posted by cosyfiep
You can play any and all of the chapters with all of your characters, there is only one area that is really inaccessible by all characters and that is pre searing, once you leave it you can never return (both factions and nightfall have a very tiny area similar to this)
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If it matters, there is also a title exclusive to Pre-Searing called Legendary Defender of Ascalon, which involves reaching level 20 in Pre-Searing. The title however is somewhat of a grindfest, and doesn't add anything to HoM beyond the normal points for adding any given title. If you want to go for it the title is there for any Prophecies character, however it isn't by any means necessary.