I've beaten Prophecies and recently beaten Nightfall (I skipped Factions because of all the negative comments I've heard about it) and there are a couple areas I am struggling hardcore on.
The first is the mission "The Last Day Dawns". So far I've only gotten up to the third group before wiping. I can never keep the NPCs alive and when the NPC priest dies its usually game over. Its incredibly frustrating because I've tried a diverse number of builds from water elementalist to air, to using fire with Winter and changing hero builds (as well as switching heroes around.)
I've done this mission so many times I can barely keep count...think its 25 times but I can't be sure...
Sometimes I often regret rolling an elementalist because I usually feel underpowered. I either feel overpowered at times, or simply very gimped. I wish I felt my class was in the middle at all times.
The second problem I have is the Domain of Anguish. I noticed they were elite missions, but I decided to try it anyway. Whenever I pull a group in the city however, I literally get torn apart unless I get lucky and down a mob or two. The farthest I've gotten here was four groups in.
I know I run with heroes and that can be a disadvantage given the brainless stupidity some of them exhibit (trust me, I've often felt like strangling them because of behaviors like deciding to run into an enemy pack to resurrect someone when I've retreated

Any tips would be greatly appreciated.
Edit - I'd like to add that I also (mistakenly) ran from Yak's; not only was it a long run going the long way, but after I went up the back entrance and destroyed two groups, the last two groups bunched together and I had to give up after multiple wipes.
I won't even try the run from Kryta...