Just want some help understanding and gearing my heroes,

Some builds suggest things like,
"Domination Wand of Memory with Aptitude not Attitude, Domination Focus of Aptitude with Forget me Not."
That, I believe is a 40/40 set if I'm right, how on earth would I come across that? Apart from drops :/
How much health should heroes have on hardmodes?
Finally, if a build suggests you to rune like:
"Survivor or Prodigy's Insignia, Vigor and Vitae Runes."
Does this mean, stack health or just one big (30/41/50 health) and the rest energy?
Regards

Josh