Cuckway build
Cuckway focuses on cucking the hell out of mobs with severe interrupts of attacks and spells, which, when combined with Frustration, causes a very high damage output. Signet of Clumsiness has good synergy with Frustration since heroes abuse the skill to its full potential. As a result of the severe spell/melee shutdown mobs cannot perform many actions at all.
The profession of the human player can be anything, although obviously certain profs are more effective than others. I personally prefer an Assassin's Promise monk or rit as the human player.
Over the course of the next few days I will be updating this post and adding another build. For now though, here is the build and associated template codes:

Hero 1. Cuckway BiP OAhjQgGaIPVvxZzOeKNncV17AA
Hero 2. Cuckway Rit OAWlEIDGIHGk7kn7BZAnZmz6NPxm
Hero 3. Cuckway MM OAhjQgGaIPVvxZzOeKNncV17AA
Hero 4. Cuckway Icy Veins OAVDEjwGP55cwFg0VEGCV1aG
Hero 5. Cuckway Mesmer 1 OQNEAawD2Cln1DkBgA2TxBhG5TB
Hero 6. Cuckway Mesmer 2 OQNEAawD2Cln1DkBgA2TxBhG5TB
Hero 7. Cuckway Mesmer 3 OQNEAawD2Cln1DkBgAuCwBhG5TB
PS: For certain areas, feel free to switch the Tease of hero 5/6 for Ineptitude.
Equipment: On the MM I use dual +15/-1 mods to bring its energy to around 83. This is so that BiP is not spammed whenever Animate Bone Fiend is cast.
The BiP itself has a spear with +5 energy and 20% enchantments plus an offhand with +30HP and 15/-1 mods.
The rest of the party can have +60hp staves or 40 recharge setup, depending on personal preference. Same goes for superior runes, go with what you prefer. I personally use a Superior Death on the Minion Master only, the rest has minor runes.