Rune health tradeoffs question

Say I use a lot of expertise, wilderness survival and marksmanship.

Superior runes for all 3? Seems like a huge health hit. When are runes worth it or not worth it? Should I always use best runes or do 2 minor + one superior, or maybe 2 major and a minor? When is the health loss a serious problem?

Regarding PVP I mean... PvE is all fairly easy with a good group anyway.

bump... anyone have a theory about health risks of runes?

I would say, and this is just me, that its just a personal preffreance. if youre focase of abillity points is markmans ship i might not use a supprior rune, but thats me, but if your taking away abbility points from beast mastery i might use a superior rune there, to offset the in ballance.
but over all i see it as a personal preffance

getting vigor runes can help offset it, altho they are quite pricey to trade for

it also depends on what type of character you are, if you are a close range character u will usually need that extra health, but if u are a spell caster or a monk that can heal yourself quickly, then taking the health hit from major or superior runes is a good trade off for the added points