Examples of single skills;
Resurrect
Purge Conditions
Antidote Signet
Frenzy
Defensive Stance
Glyph of Lesser Energy
Plague Touch
Examples where points don't matter or less is better;
Apply Poison with Fragility.
Glyph of Sacrifice with Charm Animal
Phantom Pain with Axe Rake or Axe Twist
I'll leave a few examples for other people.
Are builds that depend on "Charms" a viable option?