
When you consider those and effects such as "Infusion", it gives a lot of possibilities for extending the PvE challange.
Do people actually search for the +vs {creature} bonuses? Are there areas that I have missed where using them is critical?
If there are not, why not?

I see so much room for expansion in this game, it feels like it could be the last game I'll ever need to play. This is without even considering the great PvP aspect.
