Ctrl+Alt+Delete not working

This is kinda unrelated to GW but ill ask anyway, recently when i try to press Ctrl+Alt+Delete, the box doesnt come up, i was wondering if anyone had any idea why this is.

not sure why it happens but it is disbled for me too.....GW crashed for me once and i trried to ctrl+alt+ del and no go.....but dont know whey....had to hard boot out

When you say unrelated, in what way do you mean?

Have you tried it before playing GW and it doesn't work or while playing or after playing GW?

Be careful, some older and less sophisticated viruses are known to make the ctrl+alt+delete box disappear because you would see some weirdname.exe running (right now people know how to make it hide itself from the list). So make sure your system is clean.