When I got to ThK, I ran into a few problems. The problems seemed to lie more with my not having any knowledge of the layout and what to do and less with my build, but I felt the need to alter it anyway. I had no problem beating it with my wife and some henchies after making this build, and it seemed really fun, but I can't help to think I'm missing something.
I would just like some advice on what I should do. I'm not sure exactly what I'm going for, but I can say that I do most everything with my wife's character (R/Mo sometimes Trapper, Interrupter, or both), and we like to compliment each other, of course.
Here it is: (N/Mo)
Death - 16 (12+1+3)
Blood - 12 (11+1)
Soul Reaping - The rest (+1)
Enfeeble
Virulence (These two are left over from my MM build, never fail me

Well of Blood
Well of Suffering
Rebirth
Soul Feast
Shadow Strike
Vampiric Gaze
For this I use Kole's Torment for my weapon. Kinda low on funds so if you suggest a weapon, make sure it's fairly inexpensive to buy/make.
This becomes a great degen damager, as the Well of Suffering gives -6, and with Virulence giving Poison and Disease, each -4 degen conditions, the disease spreads and causes all mobs in the area to have -10, and the target -14 (I know -10 is max, but it does count against regen).
Well of Blood seriously helps me and my team out when help is needed, of course, while Shadow Strike and Vamp Gaze make great immediate heals and great finishers (or starters for shadow strike). Soul Feast can go, as I rarely if ever use it.
I am by no means a master of builds, as you can see... but I definately like where this one is going. Haven't acquired Well of Power yet, but not sure if I'd want to give up my Virulence. Eh, but what do I know?
Edit: As a side, this character is strictly PvE.