
Dreadnaughts Drift (midshiverpeak area) - This place to my knowledge serves no purpose except that it allows Droc Runs. The area is very small and doesn't appear to have any other significance. If this area was closed, Droc's Runs from Beacon's Perch would effecitively end
Stingray Strand - Close the area so that you have to go all the way through Magumma and Riverside Provence in order to get to Sanctum Cay. This is the final destination area for those running most of the map and would cease it.
Sanctum Cay (mission) - Make it so that the gate behind the undead unique dragon just before the cutscrene won't open unless all the bone dragons are dead. After the cut screen, make it so that all the uniques before and at the docks have to die before you the Vizier will appear on the docks.
An alternate idea to each of these would be to create a game update that made it so that if party members weren't in a certain proximity to whoever goes through the "rezone" area those members would be kicked. This would kill many runs.
On to the lesser note of farming. While we can all agree, farming for items repeatedly kind of kills the purpose of the game. However, with the elevated prices of many items in the game, farming is almost needed to be able to afford it. Also another reason for farming is to secure high end equipment which is needed for many builds and characters to survive to the level 20 cap placed on players. As it stands, many players are inexperienced in the game because they get run and this harms teams greatly. Anet has designed this game that after a certain point a person must rely on other players to be able to proceed. This game can't be (or is extremely difficult to) beat with henchies or alone. I'm not saying that old places should be reopened, but I think Anet should revaluate certain things. If they wish to nerf a farming spot, penalize those players who have taken advantage of it by taking their items. Allowing these people to keep their items puts them on unequal ground (as I stated above) compared to those who come later in the game. If a person becomes rich in guild wars, it should be hard work, not through killing the competition.
All of these are just my opinion and I'd be more than happy to discuss the subject further with anyone. I hope this sparks some interesting inquiry and gets people thinking. Please feel free to post your opinions (constructive ones) in response to this post. If you are going to post derogatory remarks because you're an "elite or pro" runner, I'm sure the moderators will be more than happy to remove them.