I prefer to go anti caster when I PvE...
Max Dom
high fast cast + inspiration
I use these skills for anti mage classes (everything but W, R, and A)
Empathy (something to do when there's no spell based classes)
Backfire
Overload (OMG this is such a wonderful new skill)
Cry of Frustration
Power Spike
Power Drain
Drain Enchant
Res sig
I basically hide in the back row and keep a sharp eye out for casters.
I gotta give my 2 cents on Overload, as it is one of the better new skills for a caster killer: 5 energy, 1/4 sec cast time, and 5 second recharge. This skill can be used well with both backfire and interrupts: Backfire alone deals excellent damage to casters as we all know, but Overload adds even more and doesn't interrupt, so catching a monk who's casting orison with backfire on them does massive damage... of course if you're fortunate enough to catch a caster in a 3 second or longer (2 seconds if you're good), you can throw in overload, and then interrupt too! I can't tell you how many times in Cantha my mesmer abused the necromancer afflicteds when they tried to raise minions... I'd throw out overload, then hit a power spike, then wait a bit, overload again on their next attempt at their overly slow spells, then CoF, and so on... the fact that it's so cheap and has great recharge makes it a wonderful and well needed bread and butter skill for an interrupter mesmer like myself. (*whew* that's more like my 20 bucks than 2 cents

)
well, I for one will be roaming cantha with my Me/N for quite some time... look me up...
Seduction Ritz, 20 Me/N.