Having played a rare bit of PvE today, there's no solace there either, unlike back in the good old days. First battle and I had 3 W's and an assassin making a beeline for me, not the monk, I spent more time kiting than fighting (OK slight exaggeration!). So whether you're PvE'ing or PvP'ing you need to cope with a load of aggro...more so than any other class except for monks, but sometimes you're an even higher priority. And correct me if I'm wrong, but seeing as this is the case we have the least options for defense and pretty much the worst self heal within our own class of any. I don't have enough A or Ri experience to comment, so I'll restrict myself to the core classes.
Mo's - not really relevant. Heal and protect thyself o holy one. Repeatedly.
W's - Duh. Well they have great armour, and with points in tactics you have a wealth of useful stances and Healing Signet which is OK. Compare HS to Ether Feast...it has half the recharge and costs no energy. I think per point in Tactics it heals more too.
R's - A primary R will usually have a load of points in Expertise anyway, with all the lovely stances that offers. Pick one and be happy. Self heal...OK you need Wilderness Survival, but a measly 6 points in WS nets you a self heal over time worth 120 Health, and with the duration equalling the recharge you can keep it up indefinitely. OK it takes 3 seconds, but Ether Feast would need 12 points in Insp to net the same health gain.
N's - Blood Magic...it damages them and also heals you. Superb if you're a specialist, but also compliments Curse / Death nicely. For Curses Parasitic Bond is just awesome, multi target spammable hex that heals you even if it's ripped off. If you're Death, eat your minions. A well played necro is quite durable.
E's - OK I might be getting onto shaky ground here. I haven't played one in ages, but Earth eles are pretty useful...Wards are nice. Their self heal does suck a bit, but one cast and you have ongoing effect. Someone fill me in here please

And now for us poor old Me's, always with a face full of warrior and annoying rangers firing pointy bits of wood into us from afar. Options...There's always Illusion with the wonderful Distortion, but Illusion has to pumped high to offset the horrible energy losses that result (8 Illusion for 2 Energy per evasion, 13 for 1 Energy per evasion). Also you have to remember to press it...continually. So Illusion is no good to us Dominators.
What does Inspiration have up it's sleeve? A crappy self heal (waiting for a flame on this one!) which I already had my say about, and some conditional Mantras. Which to take...well none of them on their own. Physical Resistance for W's?...I just hope there's not an Igniting / Kindling Ranger out there. Or an ele. Or even worse, a Conjuring W....no it's just too ugly to even think about. Within our class, our defense is diabolical.
I know we can combine classes but I don't really like weakening a build just to incorporate some defense from secondary ( if you're Dom mes you need Dom, Insp and FC really, you'd have to take from one of them) and I know we can rely on the monks but I hate doing it. Besides that's not what this post is about. I reckon at the very least we need a good defensive Domination skill, and a rethink on the others. Does anyone else feel hard done by or is it just me?
Sorry if the rant was a bit long, looking forward to your comments!