I've tried a sort of high dam / degen 'sin out. It's decent IMO.
Dagger Mastery 12 (minor rune)
Critical Strikes 13 (minor rune)
Shadow Arts 9 (minor rune)
Equipment: zealous daggers are very handy
Unsuspecting Strike (for high initial damage)
Fox Fangs (no evade / block)
Twisting Fangs (to get 'em bleeding)
Seeping Wound (to enhance twisting fangs' effect)
Viper's Defense (in, poison)
Death's Charge (out, heal)
Shadow Ref (heal)
Rez / Capt
It's quite good in PvP. In PvE with full group you don't get to use seeping wound very often because the opponent is dead before you get to that point

You can also use viper's defense before seeping wound cos' you don't have to be so close to the foe when using it. Tell me what you think and if you have any ideas for changes to make the build better.