Ive managed to combine the annoyance of constant KDs with the pressure from spikes and degen and wrap it into a nice little 5 second combo your target shouldnt see coming.
And ive decided to let it out to the public

10+2 Dagger mastery
10+2+1 Critical Strikes
7+1 Shadow Arts
9+1 Deadly Arts
Impale
Iron Palm
Falling Spider
Twisting Fangs
Moebius Strike {E}
Horns of the Ox
Shadow Refuge (or anything you want, really)
Ressurection Signet
this works fine with 15^50 zealous daggers with my favorite +5 armor daggers. As for armor, take the Keen (criticals) Mask with any choice of your armor except shrouded gloves and boots will most likely be necessary. Other than that, your free

So how it works, you just get kinda close to your target, as a cougar would track its target (:P), then do a quick Impale IMMEDIATELY followed my Iron Palm. The 3/4 cast time should stop most hex removals mid-cast. Then drop a Falling Spider to add damage+poison degen, and now they should be up and ready for more beatings. Smack em with our friendly Twisting Fangs increasing their degen to that of -7, and adding deep wound. Now they should be well below 50% health or just at it, allowing Moebius Strike {E} to do +40 damage and unlock Horns of the Ox as another KD+damage spike mix to finish those pesky backliners off

Notes: You can switch around Twisting Fangs and Horns of the Ox to get an earlier KD, but keep in mind your target may not immediately drop below 50% health as they would with bleeding and deep wound from Twisting Fangs.