Alright ..i know that sup runes decrease your health...so..i was wondering...is it wise to put a sup vigor rune into a piece of armour to counter that health loss...or do they not stack?
But also, to add, you can counter the negative loss with Fortitude Mods and Vigor runes. I have a sup in my warriors armor, but thanks to mods/vig rune, he's back over the deficit by 10 hp.