I am in the process of vanquishing Ascalon atm. I went through Flame Temple Corridor and Dragon's Gullet last night with my Dervish, MM MoW, SF Sousuke, and Boon Healer Dunk. Each of my heroes had hex removal(remove hex) and a res sig(x-cept dunk). These areas didn't have many enemies in them(about 100 each) but these charr are a pain in the ass. With armor of sanctity and conviction on my derv those blade storm/axe warriors do 0 damage to me(even with hundred blades) which eases the pressure off dunk, he has enough trouble keeping MoW alive. Once the minion army is set, killing the charr in Flame Temple is easy as pie. Only tough areas was the first staircase to ur left when u get into actual temple area, there was 5 chaot and a shaman. Enchantment stripping ftl. In the end SF took em down, put fire attune and AoR(as a cover enchantment) on Sousuke and disabled all of his spells except for SF and Mark of Rodgort, called a target, and watched them roast. Combined with AoE Scythe Attacks(Wounding Strike and Chilling Victory FTW) they fell surprisingly easily. Another tough spot was an area with 2 shaman, 2 melee guys, ashen claw, and chaot couldn't separate them. Killed the warriors with SF spike and the minions killed one of the shaman and almost got the other one before we got wiped. I was the only one left alive. Res'd dunk and got the last 3 guys. Dragon's Gullet was a pain as well with all the Hydras.
My tips are: (don't know if these have already been said, but here it goes)
In 4 person areas:
1.) The team I described above works really good but depends on your class.
2.) Everyone needs a res.
3.) Do whatever is necessary to avoid 60DP boot.(flag one hero(with res) away)
4.) If you know where pop-ups are, avoid them as they don't count to vanquisher unless triggered.
5.) Human monk is necessary with mission critical NPC's(Rurik=retarded)
In 6 person:
1.) 2 monks, MM, Tank, dual SF(<-most effective but not necessary)
2.) Everyone whould still have res.
3.) 60DP boot shouldn't be as big a problem as it was with 4 people.
4.) With 6 people you could remove an SF ele for a BHA ranger(lengthen daze bow) as soft interrupts are hard to execute with the monsters 50% faster cast.
In 8 peson:
Really shouldn't be a problem. Still bring res, 2-3 monks, MM or 2, SF eles are always nice, interrupts, tank or 2.
P.S. - Vanquisher Title = great excuse to do cartographer as well